Mild phosphoribosylpyrophosphate synthetase superactivity

由 江依萍 著作 · 2013 — Phosphoribosyl pyrophosphate (PRPP) plays the role of an important precursor on nucleotide synthesis/metabolism, which involved in de novo and salvage pathway ...

Phosphoribosylpyrophosphate synthetase superactivity (PRS superactivity) is characterized by the overproduction and accumulation of uric acid (a waste ...

Ribose-phosphate diphosphokinase is an enzyme that converts ribose 5-phosphate into phosphoribosyl pyrophosphate (PRPP). It is classified under EC 2.7.6.1.

PRPP synthetase has an absolute requirement for inorganic phosphate (Pi), which functions as an allosteric activator. The enzyme is inhibited by many ...

由 S Fujimori 著作 · 1996 · 被引用 5 次 — PRS superactivity is an X-chromosome linked disorder, characterized by gout and uric acid overproduction resulting from accelerated synthesis of PRPP and purine ...

由 B Hove-Jensen 著作 · 2017 · 被引用 163 次 — PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is ...

由 W Zhou 著作 · 2019 · 被引用 18 次 — PRPP synthetase is an important enzyme that produces a key metabolic intermediate necessary for the biosynthesis of purine and pyrimidine ...

A mild form of phosphoribosylpyrophosphate (PRPP) synthetase superactivity, an X-linked disorder of purine metabolism, characterized by adolescent or early ...

2022年8月2日 — 6.1) is a rate-limiting enzyme that irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5-phosphate and ...