Orthotopic vs. Xenograft Models of Cancer

由 RM Hoffman 著作 · 1999 · 被引用 705 次 — Effective drugs can be discovered and evaluated in the SOI models utilizing human tumor cell lines and patient tumors. These unique SOI models have been used ...

Luciferase-based tumor models: Tumor cells are implanted into the mice (orthotopic or intravenous for tumor cell growth in the bone marrow). When appropriate ...

由 LE McVeigh 著作 · 2019 · 被引用 22 次 — In summary, this method has successfully demonstrated the development of a minimally-invasive model of CRCLM and CCA. The relatively quick and ...

2020年11月26日 — Step-By-Step Method Details. This protocol is aimed at injecting HCC cells orthotopically in preconditioned liver with high-fat diet feeding.

由 YY Cai 著作 · 2022 — Each model has its own advantages. The subcutaneous model, as a representative of the heterotopic model, is easy to implant and subsequently ...

Charles River offers orthotopic models across a broad range of histotypes to support your research needs. Orthotopic mouse models, involving tissue-specific ...

In medicine, refers to something that occurs in the normal or usual place in the body. It is often used to describe tissue or an organ that is transplanted ...

由 W Qiu 著作 · 2013 · 被引用 102 次 — Genetically engineered mouse models of pancreatic cancer that recapitulate human pancreatic tumorigenesis have been established.

Orthotopic xenograft models seem to more closely mimic the tumor micro-environment and metastases as observed in human prostate cancer patients according to ...