由 S Tahtinen 著作 · 2022 · 被引用 160 次 — IL-1ra is the primary regulator of responses to RNA-LPX. To test directly whether the high systemic levels of IL-1ra explained the marked ...
由 CA Dinarello 著作 · 1997 · 被引用 968 次 — IL-1Ra is structurally similar to IL-1beta but lacking agonist activity is used in clinical trials to reduce disease severity. In addition, regulation of IL-1 ...
由 WP Arend 著作 · 1993 · 被引用 790 次 — IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by ...
由 V Volarevic 著作 · 2010 · 被引用 214 次 — There are mounting evidences to suggest that anti-inflammatory IL-1Ra reduces the inflammatory effects of IL-1 and preserves cell function in both types of ...
This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and ...
由 WP Arend 著作 · 1998 · 被引用 1399 次 — The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response.
由 CA Dinarello 著作 · 2018 · 被引用 1460 次 — The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share ...