beta-catenin

4 天前 — beta-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers.

Beta-catenin is the central component of the Wnt signaling pathway, with a key role in the regulation of cell proliferation, differentiation, and apoptosis. In ...

由 K Willert 著作 · 1998 · 被引用 1008 次 — Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is ...

β-Catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is ...

因此本計畫最終目標為建立一個b-catenin 啟動子之報導基因平台，利用該模式篩選出具有抗血癌的先導藥物，並評估該藥物體外與體內之藥理活性。 ... 藉由本計畫體外到體內的 ...

第二年： 利用專一性Wnt/β-Catenin/TCF 訊號傳遞的shRNA 或小分子結抗劑，從功能上降低Wnt/ β-Catenin/TCF 訊號傳遞的調控對於肝癌幹細胞的影響，此外亦將利用冷光報導基因 ...

由 J Liu 著作 · 2022 · 被引用 437 次 — The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.

β-連環蛋白（β-catenin），也叫連環蛋白β-1（Catenin beta-1），是一種雙重功能蛋白質，參與細胞-細胞黏附和基因轉錄的調節和協調。在人類中，β-連環蛋白由CTNNB1基因 ...