These Statins inhibit the action of enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase) that catalyzes the rate-limiting step in ...
A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG-CoA reductase inhibitor ...
Statins act by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. Because statins are similar in structure to HMG- ...
由 JA Tobert 著作 · 2003 · 被引用 1086 次 — Inhibition of HMG-CoA reductase reduces levels of mevalonate, which leads to a reduction in the regulatory sterol pool, which in turn causes ...
由 A Markowska 著作 · 2020 · 被引用 16 次 — Statins, also known as HMG-CoA inhibitors, are a class of bioactive small molecules that efficiently reduce the levels of cholesterol, ...
HMG CoA reductase inhibitors inhibit mesangial cell proliferation and production of macrophage chemotactic factors, thereby slowing down renal disease ...
2021年4月28日 — β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, more popularly known as statins, work by reducing the cholesterol levels in ...